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Semin Med Pract 
2007 ;10:18-29
Applying evidence to the care of a patient with cardiovascular disease: How to detect misleading claims in clinical research reports
Shaneyfelt T, Montori VM

The article, the latest in an ongoing series devoted to evidence-based medicine, uses a recently published randomized controlled trial (RCT) to illustrate that biased or misleading interpretations of study results can occur even if the study was methodologically sound. Using a case of a patient with a prior myocardial infarction, the authors discuss how to evaluate the results of the RCT to form a more objective conclusion about whether adding clopidogrel to the patientís cardiovascular regimen would indeed be beneficial. The authors present 6 strategies physicians can apply to help detect biased or misleading inferences when reading original research reports.

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