Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions


Answer 4
  1. Prednisone. In the past, most physicians reserved steroid therapy for patients unfit for surgery or with extensive involvement of the main vessels. However, studies that have demonstrated success with steroid administration combined with modern imaging techniques (to obtain percutaneous biopsies to rule out malignancy) have led to the use of glucocorticoids alone or in combination with other immunosuppressive agents as an alternative primary treatment.5 Most treatment successes of RPF as described by case reports in the literature have used steroid monotherapy. Additional studies have shown that tamoxifen, a nonsteroidal antiestrogen, and immunosuppressive agents such as azathioprine, cyclophosphamide, mycophenolate mofetil, and penicillamine, are effective medical therapies for RPF. Immunosuppressive agents are usually used in combination with a reduced dose of steroids.

    5. Kardar AH, Kattan S, Lindstedt E, Hanash K. Steroid therapy for idiopathic retroperitoneal fibrosis: dose and duration. J Urol 2002;168:550-5.

Click here to return to the questions


Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 1/04/08 • kkj