All of the medications listed have been implicated in the development of RPF. However, the most well-known medication-related cause of RPF is prolonged use of methysergide and other ergot alkaloids (ie, LSD). The reported incidence of RPF in long-term methysergide users (a medication used for the prevention of recurrent migraine headaches) is 1%.2 The pathophysiology of drug-induced RPF is unknown.
REFERENCES 2. Graham JR, Suby HI, LeCompte PR, Sadowsky NL. Fibrotic disorders associated with methysergide therapy for headache. N Engl J Med 1966;274:359-68.