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Answer 6
  1. Biopsy of the penile lesion. The patient may have carcinoma of the penis. Biopsy of the lesion is necessary before initiation of therapy. No harmful effects have been associated with tumor dissemination secondary to biopsy. The majority of penile tumors are squamous cell carcinomas, which demonstrate keratinization, epithelial pearl formation and various degrees of mitotic activity. Radiation therapy may be considered in a select group of patients after the diagnosis of penile cancer is established. Topical antibiotic therapy is appropriate if the possibility of penile cancer has been excluded. Topical chemotherapy with 5-fluorouracil is an appropriate treatment for superficial premalignant lesions.

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