Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions


Answer 2
  1. Symmetrical joint space narrowing. Osteoarthritis can be thought of as a localized process in which mechanical forces are distributed in an unequal fashion over the joint surface, resulting in asymmetrical joint space narrowing. In contrast, the inflammatory arthropathies are mediated by the generation of soluble factors such as interleukin-6 and tumor necrosis factor alpha, which affect the cartilage in a global manner and result in symmetrical joint space narrowing. New bone formation is characteristic of osteoarthritis but is not unique to osteoarthritis, because new bone formation can also be seen in Paget’s disease. Subchondral cysts appear in a variety of advanced joint diseases.

Click here to return to the questions


Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 1/04/08 • kkj