The largest trial of a volume- and pressure-limited strategy showed a 9% decrease in all-cause mortality in patients ventilated with tidal volumes of 6 mL/kg of estimated lean body weight as compared with a tidal volume of 12 mL/kg (target plateau pressure, < 30 cm H2O).3 Based on the results of this study, a strategy of using low tidal volume and high PEEP is recommended for mechanical ventilation of acute lung injury/ARDS patients.
- Increase PEEP.
3. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;
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