Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Interactive:
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Quiz
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Exams
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions

Pulmonary Disease


Answer 1
  1. Although there are a few hundred mutations that exist for CF, the most prevalent mutation among northern Europeans is W1282X. CF is an autosomal recessive disorder of adults and children. More than 700 genetic mutations contribute to the development of CF. The most prevalent mutation of CFTR is deletion of a single phenylalanine residue at amino acid 508 (Delta F508). This mutation is responsible for the high incidence of CF in northern Europeans. The W1282X mutation is most common among the Ashkenazi Jewish population.

Click here to return to the questions

 

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 1/04/08 • kkj