Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Interactive:
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Quiz
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Exams
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions

Psychiatry


Answer 8
  1. Serotonin syndrome. Serotonin syndrome is characterized by autonomic instability, neuromuscular abnormalities, and altered level of consciousness. Selegiline is a type B monoamine oxidase inhibitor that inhibits the catabolism of dopamine and enhances dopamine activity. Development of serotonin syndrome is a rare but possible side effect of combining selegiline and SSRIs.13 Although selegiline use is not an absolute contraindication to an SSRI trial,11 the risk should be considered and discussed with the patient before initiating an SSRI.

    REFERENCES
    11. Okun MS, Watts RL. Depression associated with Parkinson’s disease: clinical features and treatment. Neurology 2002;58(4 Suppl 1):S63-70.

    13. Ritter JL, Alexander B. Retrospective study of selegiline-antidepressant drug interactions and a review of the literature. Ann Clin Psychiatry 1997;9:7-13.

Click here to return to the questions

 

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 1/31/08 • kkj