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Orthopaedic Surgery

Answer 6
  1. t(11;22). Based on the histology (small round blue cells) and clinical history, the patient has Ewing’s sarcoma. Ewing’s sarcoma is the second most common primary malignant bone tumor in children, with 80% occurring in patients younger than age 20 years.1 Cytogenic studies have shown that 85% of Ewing’s sarcomas contain the t(11;22) translocation. Burkitt’s lymphoma, chronic myelogenous leukemia (Philadelphia chromosome), synovial sarcoma, and dermatofibrosarcoma protuberans contain the t(8;14), t(9;22), t(X;18), and t(17;22) translocations, respectively.

     Gibbs CP Jr, Weber K, Scarborough MT. Malignant bone tumors. Instr Course Lect 2002;51:413-28.

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