Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions

Orthopaedic Surgery

Answer 5
  1. McCune-Albright syndrome. McCune-Albright syndrome is a condition with the classic triad of polyostotic fibrous dysplasia, cutaneous café au lait spots, and endocrine dysfunction.5 Precocious puberty and vaginal bleeding are also common in young female patients with McCune-Albright syndrome. Bone lesions typically have a ground-glass appearance on radiography and occur most commonly in the femur (91%) and tibia (81%).5 Letterer-Siwe disease (fulminant fatal form of histiocytosis X) and Hand-Schüller- Christian disease (classic triad of exophthalmus, diabetes insipidus, and lytic skull lesions) are associated with eosinophilic granulomatous lesions, not fibrous dysplasia. Paget’s disease is a form of abnormal bone remodeling found in adults. Gardner’s syndrome is an autosomal dominant disorder manifested in childhood by multiple neoplasms (ie, bone and mesenteric tumors, fatty and fibrous skin, and intestinal polyps).

     Parekh SG, Donthineni-Rao R, Ricchetti E, Lackman RD. Fibrous dysplasia. J Am Acad Orthop Surg 2004;12:305-13

Click here to return to the questions


Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 3/20/08 • nvf