Oncology

Answer 2 H. pylori. Various infectious agents have been associated with lymphomas of the gastrointestinal tract; however, Giardia species, Salmonella species, and E. coli are not known to be among them.C. jejuni has been associated with immunoproliferative small intestinal disease, a rare form of lymphoma that arises in small intestinal MALT but not in the stomach.2 H. pylori is the most common causative agent of MALT lymphomas of the stomach. MALT lymphoma is unusual in that, when associated with H. pylori, it can frequently be cured with antibiotic/antacid regimens that eliminate the bacterial pathogen.3 More advanced cases or cases refractory to antibiotics are treated with radiation therapy or chemotherapy. The prognosis is generally good. REFERENCES 2. Lecuit M, Abachin E, Martin A, et al. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med 2004;350:239-48. 3. Fischbach W, Goebeler-Kolve ME, Dragosics B, et al. Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series. Gut 2004;53:34-7. Click here to return to the questions

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