contrary, most patients with pancreatic adenocarcinoma have unresectable tumors.
In the United States, it is estimated that as many as 80% of patients initially
diagnosed with pancreatic cancer will already have locally advanced or metastatic
disease. The majority of these patients are in their 60s and 70s, present with
obstructive jaundice, and have tumors in the head of the gland. Several studies
have documented the lack of survival benefit for patients undergoing operative
resection with disease extending beyond the pancreas into contiguous organs or
to vascular structures without frank metastases. Unfortunately, most patients
have tumors that extend beyond the pancreas or invade adjacent structures. Even
following pancreatic resection, patients with pancreatic adenocarcinoma have less
than a 10% chance for a 5-year survival. Survival beyond 2 years following
diagnosis is uncommon.
- The majority of affected patients have surgically resectable tumors.
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