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Self-Assessment Questions


Hodgkin’s Disease: Review Questions

Eric Jacobsen, MD

Dr. Jacobsen is an instructor in medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Choose the single best answer for each question.

1. Which of the following is associated with Hodgkin’s disease?
  1. Cytomegalovirus
  2. Epstein-Barr virus (EBV)
  3. Helicobacter pylori
  4. Human herpes virus 8
  5. Measles virus
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2. A 26-year-old woman just completed therapy for Hodgkin’s disease with doxorubicin, bleomycin, vinblastine, and dacarbazine, followed by radiation therapy to the neck and mediastinum. All of the following are potential long-term complications of this treatment regimen EXCEPT

  1. Acute myelogenous leukemia (AML)
  2. Breast cancer
  3. Hypothyroidism
  4. Melanoma
  5. Valvular heart disease
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3. A 38-year-old man was recently diagnosed with stage II (mediastinal and supraclavicular lymph node involvement) nodular sclerosis Hodgkin’s disease. The largest lymph node measures 5 cm in diameter. He has lost 5 lb since his diagnosis 4 weeks ago. Which of the following is associated with a less favorable prognosis in this patient?
  1. Age
  2. Gender
  3. Histologic subtype (ie, nodular sclerosis)
  4. Mediastinal involvement
  5. Weight loss
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4. All of the following are correct pairings of a chemotherapy agent with a potential side effect EXCEPT

  1. Bleomycin can induce pneumonitis
  2. Bleomycin can induce Raynaud’s phenomenon
  3. Dacarbazine can cause hemorrhagic cystitis
  4. Doxorubicin can cause cardiomyopathy
  5. Vinblastine can cause constipation
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