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Obstetrics & Gynecology

Answer 1
  1. Pituitary tumor. Adrenal tumors do not secrete prolactin and are not a cause of hyperprolactinemia associated with galactorrhea. Frequent breast manipulation; phenothiazines, reserpine, opiates, and amphetamines; primary hypothyroidism; and pituitary tumors are all associated with hyperprolactinemia. Of these possible causes of GA syndrome, pituitary tumor is the most serious. Galactorrhea caused by breast manipulation or medications is usually resolved with discontinuation of the manipulation or medication. Galactorrhea caused by primary hypothyroidism is treated with thyroid hormones, which usually brings the serum levels of prolactin to normal levels and consequently resolves galactorrhea. The pituitary tumor, if not treated promptly and adequately, may enlarge and create pressure on the adjacent organs causing headaches, vision disturbances, and a decrease in pituitary hormone secretion.

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