Obstetrics & Gynecology
Low-dose postmenopausal HRT has been shown
to improve peripheral insulin resistance, prevent hyperinsulinemia, and reduce
the risk for type 2 diabetes mellitus. In fact, the cardiovascular benefits of
HRT may significantly help patients with diabetes mellitus. Estrogen is
metabolized in the liver; therefore, HRT is contraindicated in patients
with chronically impaired liver function. Endometrial adenocarcinoma is
almost always an estrogen-sensitive cancer, and HRT is accordingly
contraindicated. Breast cancer also is often an estrogen-sensitive cancer.
After primary treatment of the breast cancer, metastatic cells may still be
present and susceptible to exogenous hormones. Hypertriglyceridemia and
pancreatitis can be precipitated by HRT administration in women with
triglyceride levels between 250 and 750 mg/dL.
- Impaired glucose tolerance.
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