Weight gain has been absolved as an adverse effect of HRT.
The Rancho Bernardo and Postmenopausal Estrogen/Progestogen Intervention studies
found no significant weight difference between women who did and did not use
hormones. Uterine bleeding, abdominal bloating, breast tenderness, weight gain,
and fluid retention in extremities are common adverse effects of HRT, which can
decrease patient compliance and lead to discontinuance of therapy.