Neurology

	Answer 2 HSV. Of the organisms mentioned, HSV has a predilection for the limbic system of the temporal lobe and is most likely to cause sharp wave discharges in the temporal lobes but no electrographic seizures on EEG. In a majority of cases of herpes simplex encephalitis, the EEG is abnormal and shows focal temporal changes known as periodic lateralized epileptiform discharges, which consist of repetitive spike or sharp wave discharges that are focal or lateralized over 1 hemisphere, recur at intervals of 0.5 to 5 seconds, and continue throughout most of the duration of an EEG. Periodic lateralized epileptiform discharges are often seen in the setting of unilateral lesions such as cerebral infarctions, encephalitis, or tumors. Click here to return to the questions
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