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Self-Assessment Questions


Neurosarcoidosis: Review Questions

Bertrand C. Liang, MD

Dr. Liang is Adjunct Associate Professor of Medicine and Neurology, University of Vermont College of Medicine, Burlington, VT, and a member of the Hospital Physician Editorial Board.

Choose the single best answer for each question.

1. Neurosarcoidosis most often involves which of the following structures of the nervous system?
  1. Muscle
  2. Meninges
  3. Cerebellum
  4. Cortex
  5. Peripheral nerve
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2. A tissue sample positive for neurosarcoidosis exhibits nodules composed of all of the following cell types EXCEPT:

  1. Astrocytes
  2. Lymphocytes
  3. Endothelial cells
  4. Giant cells
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3. The cranial nerve most frequently involved in neurosarcoidosis is:

  1. VII
  2. III
  3. II
  4. IV
  5. I
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4. All of the following are neurosarcoid-associated syndromes EXCEPT:

  1. Aseptic meningitis
  2. Diffuse encephalopathy with vasculopathy
  3. Amyloidosis
  4. Seizures
  5. Hypothalamic syndrome
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5. All of the following laboratory data are supportive of sarcoidosis EXCEPT:
  1. Increased serum globin levels
  2. Increased serum calcium levels
  3. Increased serum/cerebrospinal fluid angiotensin converting enzyme (ACE) levels
  4. Positive skin-tuberculin reaction
  5. Increased glycol-precipitable immunoglobulin levels
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6. Which of the following choices best describes how the diagnosis of neurosarcoidosis is made?

  1. Clinically
  2. By a history of cranial neuropathy and an elevated ACE level in serum
  3. By confirmatory biopsy of a nodule and a history of neurologic signs or symptoms
  4. Only at autopsy
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7. The differential diagnosis of neurosarcoidosis includes all of the following EXCEPT:

  1. Hodgkin’s lymphoma
  2. Non-Hodgkin’s lymphoma
  3. Syphilis
  4. Multiple sclerosis
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