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Answer 2
  1. Freckling in the axillary region. Freckling in the axillary region is one of the specific clinical criteria of NF1; other criteria include neurofibromas (≥ 2 or 1 plexiform), 2 or more Lisch nodules, a distinctive osseus lesion or thinning of the long bone cortex with or without pseudoarthritis, and a first-degree relative with NF1. As noted above, café au lait spots are the hallmark of the disorder, and optic glioma occurs frequently. Lens opacities occur in NF2. Retinal angiomas are found in Von Hippel-Lindau Syndrome, ashleaf spot occurs in tuberous sclerosis, and skin pits on palms and soles are a manifestation of Gorlin syndrome.

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