Neurology

Answer 1 The male-to-female ratio of persons affected by MS is 2:1. On the contrary, the female-to-male ratio in multiple sclerosis (MS) is approximately 2:1. MS is an immune-mediated inflammatory disease and is the most common neurologic disorder affecting young adults. It affects millions worldwide and approximately 400,000 in the United States alone. Whereas the risk for MS occurring in the general population is 0.1%, the risk is 25% to 30% for MS occurring in a monozygotic twin and 3% to 5% in a dizygotic twin.1-3 REFERENCES 1. Compston A, Coles A. Multiple sclerosis [published erratum appears in Lancet 2002;360:648]. Lancet 2002;359:1221-31. 2. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med 2000;343:938-52. 3. Keegan BM, Noseworthy JH. Multiple sclerosis. Annu Rev Med 2002;53:285-302. Click here to return to the questions

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