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Self-Assessment Questions

Neurology

Multiple Sclerosis: Review Questions

Gokhan L. Akfirat, MD

Dr. Akfirat is an Instructor of Neurology, New York Medical College, Metropolitan Hospital, New York, NY.



Choose the single best answer for each question.

1. Which of the following statements regarding multiple sclerosis (MS) is NOT correct?
  1. MS is an immune-mediated disease
  2. MS is the most common neurologic disorder affecting young adults
  3. The male-to-female ratio in persons affected by MS is 2:1
  4. The risk for MS in a monozygotic twin is 25% to 30%
  5. The risk for MS in the general population is 0.1%
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2. A 31-year-old woman with a history of MS, including 2 exacerbations with complete recovery in the past 2 years, develops optic neuritis. She is treated with methylprednisolone sodium succinate, intravenously, and experiences complete resolution of her symptoms in 3 weeks. Which of the following types of MS does the patient most likely have?

  1. Primary progressive
  2. Progressive-relapsing
  3. Relapsing-remitting
  4. Secondary progressive
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3. Which of the following is associated with a better prognosis in a patient with MS?

  1. Brainstem and cerebellar symptoms
  2. Disease onset after age 35 years
  3. Female gender
  4. Higher incidence of attacks
  5. Poor recovery after an exacerbation
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4. Which of the following agents is NOT typically used to manage fatigue in patients with MS?
  1. Amantadine
  2. Baclofen
  3. Fluoxetine
  4. Methylphenidate
  5. Pemoline
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5. Which of the following statements regarding cognitive function in patients with MS is NOT correct?

  1. Cognitive dysfunction has no association with disruption of daily activities in most patients with MS
  2. Cognitive dysfunction is related to brain atrophy and total lesion burden as seen on magnetic resonance imaging
  3. Cognitive dysfunction observed in patients with MS includes but is not limited to memory loss, inattention, slow information processing, and difficulty with abstract concepts
  4. Cognitive function is affected in approximately 45% to 60% of patients with MS
  5. Demyelination in the frontal lobes and corpus callosum is more often associated with cognitive dysfunction than is demyelination in other parts of the brain
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