The inheritance pattern of Huntingtons disease
has been defined as autosomal dominant with nearly complete penetrance.8
Linkage analysis demonstrated localization of the Huntingtons disease
gene to the short arm of chromosome 4 in 1983,9 with the genetic
mutation delineated 10 years later.10
- Autosomal dominant.
8. Conneally PM. Huntington disease: genetics and epidemiology.
Am J Hum Genet 1984;36:506-26.
9. Gusella JF, Wexler NS, Conneally PM, et al. A polymorphic
DNA marker genetically linked to Huntingtons disease. Nature
10. The Huntingtons Disease Collaborative Research Group.
A novel gene containing a trinucleotide repeat that is expanded and
unstable on Huntingtons disease chromosomes. Cell 1993;72:971-83.
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