Neurology

Answer 5 Autosomal dominant. The inheritance pattern of Huntington’s disease has been defined as autosomal dominant with nearly complete penetrance.8 Linkage analysis demonstrated localization of the Huntington’s disease gene to the short arm of chromosome 4 in 1983,9 with the genetic mutation delineated 10 years later.10 REFERENCES 8. Conneally PM. Huntington disease: genetics and epidemiology. Am J Hum Genet 1984;36:506-26. 9. Gusella JF, Wexler NS, Conneally PM, et al. A polymorphic DNA marker genetically linked to Huntington’s disease. Nature 1983;306:234-8. 10. The Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 1993;72:971-83. Click here to return to the questions

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