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Self-Assessment Questions


Movement Disorders: Review Questions

Donald S. Higgins, Jr., MD

Dr. Higgins is an Associate Professor, Center for Neuropharmacology and Neuroscience and Department of Neurology, Albany Medical College, Albany, NY; and a member of the Hospital Physician Editorial Board.

Choose the single best answer for each question.

1. The primary neurochemical disturbance in idiopathic Parkinson’s disease involves which of the following neurotransmitters?
  1. Gamma-aminobutyric acid
  2. Dopamine
  3. Glutamate
  4. Serotonin
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2. Which of the following pathologic abnormalities are characteristically found in patients with Parkinson’s disease?

  1. Corpora amylacea
  2. Lewy bodies
  3. Neurofibrillary tangles
  4. Pick bodies
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3. Parkinson’s disease is characterized by each of the following clinical symptoms EXCEPT:

  1. Action tremor
  2. Bradykinesia
  3. Postural instability
  4. Resting tremor
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4. Which of the following symptoms or symptom complexes must be present to diagnose Tourette’s syndrome?

  1. Coprolalia
  2. Multiple motor tics present for 6 months
  3. Multiple motor and phonic tics present for 12 months
  4. Vocal tics present for 3 months
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  5. What is the genetic inheritance pattern of Huntington’s disease?
  1. Autosomal dominant
  2. Autosomal recessive
  3. Maternal
  4. X-linked
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6. What is the gene mutation present in Huntington’s disease?

  1. Frameshift mutation
  2. Mitochondrial DNA deletion
  3. Nuclear point mutation
  4. Trinucleotide repeat expansion
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7. Which of the following is the most common tardive, drug-induced movement disorder?

  1. Chorea
  2. Myoclonus
  3. Orolingual dyskinesia
  4. Tremor
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