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Answer 3
- Brain metastasis.
Absolute contraindications for anticoagulant therapy are active bleeding, platelet count less than 20 × 103/µL, history of neurosurgery or ocular surgery, and intracranial bleeding within the past 10 days. Brain metastasis, gastrointestinal bleeding within the past 14 days, and severe hypertension are the relative contraindications to anticoagulant treatment.
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