Internal Medicine

Answer 4 Intramuscular doses of cefoxitin and oral administration of doxycycline are part of the outpatient therapy of PID. The outpatient regimen of cefoxitin and doxycycline covers all PID pathogens. Antibiotic therapy has not yet been proven to decrease complications of PID. Antibiotic therapy is empiric and broad-spectrum; it is not based on culture results. Hospital therapy is not superior to outpatient treatment in randomized, controlled studies.2 Intravenous administration of ciprofloxacin alone is not adequate therapy for PID. The CDC recommends intravenous administration of cefoxitin and oral administration of doxycycline for inpatient therapy.1 REFERENCES 1. 1998 guidelines for treatment of sexually transmitted diseases. Centers for Disease Control and Prevention. MMWR Recomm Rep 1998;47(RR-1):1-111. 2.  Ness RB, Soper DE, Holley RL, et al. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) Randomized Trial. Am J Obstet Gynecol 2002;186:929-37. Click here to return to the questions

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