Tricuspid valve endocarditis typically occurs in IV drug users and presents with fever and pulmonary symptoms due to septic emboli from friable valvular vegetations. An inspiratory systolic murmur at the right sternal border may be noted. Most cases of tricuspid endocarditis result from Staphylococcus aureus that is treated with
4 weeks of IV antibiotics, although some studies support a 2-week course in selected, low-risk patients. The majority of patients with tricuspid endocarditis do not require valve replacement or repair.