suppressive antiviral therapy reduces recurrences of genital herpes by at least
75% in persons who have 6 or more recurrences per year. Valacyclovir may be given
once daily as suppression (at doses of 500 or 1000 mg), but acyclovir (400 mg)
and famciclovir (250 mg) require twice-daily dosing. Antiviral suppression is also
effective for prevention of recurrent genital lesions caused by herpes simplex type 1
infection. Severe initial episodes of genital herpes do not predict more frequent or
severe recurrences. Suppressive therapy has been shown, in rare cases, to cause
antiviral resistance in immunosuppressed patients but not in immunocompetent patients.
- Appropriate for patients who have 6 or more recurrences per year.
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Seminars in Medical Practice
Hospital Physician Board Review Manuals
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