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Self-Assessment Questions

Internal Medicine

Genital Herpes Simplex: Review Questions

Kenneth J. Smith, MD, FACP

Dr. Smith is an Associate Program Director, Internal Medicine and Transitional Residency Programs, Mercy Hospital of Pittsburgh, Pittsburgh, PA; and a member of the Hospital Physician Editorial Board.


Choose the single best answer for each question.

1. Approximately how many clinical visits in the United States each year involve genital herpes­related illness?
  1. 50,000
  2. 100,000
  3. 500,000
  4. 1,000,000
  5. 2,000,000
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2. What portion of the US population has serologic evidence of prior herpes simplex type 2 infection?

  1. 4%
  2. 8%
  3. 13%
  4. 17%
  5. 22%
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3. Which of the following statements regarding the transmission of genital herpes is correct?

  1. Absence of lesions means that transmission of the disease is not possible
  2. Condoms are effective in decreasing the transmission of the disease
  3. Crusted lesions are not infectious
  4. Lesions from recurrences are less infectious than are primary lesions
  5. Suppressive antiviral therapy of genital herpes prevents viral transmission
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  4. Antiviral regimens that are appropriate for the treatment of an initial episode of genital herpes include each of the following EXCEPT:
  1. Acyclovir 200 mg orally 5 times daily for 7 to 10 days
  2. Acyclovir 400 mg orally 3 times daily for 7 to 10 days
  3. Famciclovir 250 mg orally 3 times daily for 7 to 10 days
  4. Ganciclovir 1000 mg orally 3 times daily for 7 to 10 days
  5. Valacyclovir 1 g orally twice daily for 7 to 10 days
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5. Antiviral regimens that are appropriate for the treatment of a recurrence of genital herpes include each of the following EXCEPT:

  1. Acyclovir 5% ointment applied to lesions 5 times daily for 5 days
  2. Acyclovir 400 mg orally 3 times daily for 5 days
  3. Acyclovir 800 mg orally twice daily for 5 days
  4. Famciclovir 125 mg orally twice daily for 5 days
  5. Valacyclovir 500 mg orally twice daily for 5 days
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6. Which of the following characterizations of chronic antiviral suppression for recurrent genital herpes is correct?

  1. Appropriate for patients who have 6 or more recurrences per year
  2. Effective with once-daily dosing for all antiviral agents
  3. Ineffective if lesions are caused by herpes simplex type 1 infection
  4. Recommended after severe initial episodes of genital herpes
  5. Responsible for antiviral resistance in immunocompetent patients
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Updated 1/04/08 • kkj