HGV and GBV-C have a greater than 95% global sequence and amino acid homology.5 HGV/GBV-C is a single-stranded, positive-sense RNA virus and is considered a new genus within the Flaviviridae family. Studies have consistently shown the lack of influence of HGV/GBV-C on the clinical, biochemical, histologic, and virologic course of coexistent HCV infection.5 Unexpectedly, several studies have shown that HIV-infected patients who are coinfected with HGV/GBV-C fare better in terms of overall survival, interval to development of AIDS, and duration of survival after the onset of AIDS.5 The exact mechanism for this phenomenon remains unclear.
- Patients with HCV and a coexisting HGV/GBV-C infection have a clinically more severe course of illness than those with HCV alone.
5. Mandell G, Bennett J, Dolin R, editors. Principles and practices of infectious diseases. 6th ed. Philadelphia: Elsevier; 2005.
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