Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Past Issue Archives
Self-Assessment Questions
Review of
Clinical Signs
Clinical Review
Pediatric Rounds
Resident Grand Rounds
Article Archives
Case Reports
Clinical Practice
Pediatric Rounds
Resident Grand Rounds
Review of
Clinical Signs

Guide to Reading
Hospital Physician
Editorial Board
Information for Authors

Reprints, Permissions, & Copyright
Site Map
Self-Assessment Questions

Infectious Diseases

Answer 2
  1. Repeat the test after 2 weeks to check for a booster reaction. The delayed hypersensitivity response to Mycobacterium tuberculosis in infected persons may decline over time. Therefore, in previously infected individuals, an initial tuberculin skin test (TST) may show negative results but may "boost" the response to a second TST. This boosted positive reaction may be misinterpreted as a conversion reaction, implying recent infection. Two-step testing is therefore recommended for the initial tuberculin skin testing of adults such as health care workers who will be tested periodically. If the initial TST is negative, a repeat TST should be performed 1 to 3 weeks later. If the result is positive, the person should be considered infected and treated accordingly; if the result is negative, the person is not infected.1

     Core curriculum on tuberculosis. 4th ed. Centers for Disease Control and Prevention, Division of Tuberculosis Elimination; 2000. Available at http://www.cdc.gov.nchstp/tb/pubs/corecurr/default.htm.

Click here to return to the questions


Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2009, Turner White Communications
Updated 1/04/08 • kkj