Whenever lymphoma involves the
bone marrow, there is a high risk that peripheral blood stem cells
will also be contaminated by tumors. For large B-cell lymphoma,
Hodgkins disease, anaplastic large cell lymphoma, and peripheral
T-cell lymphoma, the incidence of bone marrow involvement ranges
from 5% to 20%. Even in these histologic types of lymphoma, a bone
marrow examination is necessary to rule out lymphomatous involvement
prior to harvesting stem cells for purposes of transplantation.
However, the incidence of bone marrow involvement in small cleaved
cell lymphoma is dramatically higher; 60% to 70% of cases have
involvement of the bone marrow on microscopic examination.
Additionally, when the bone marrow does not appear to be involved
in small cleaved cell lymphoma, about two thirds of cases have
bone marrow involvement when assessed by molecular genetic studies
looking for bcl-2 or heavy chain gene rearrangement.3
- Small cleaved cell lymphoma.
3. Berinstein NL, Reis MD, Ngan BY, et al. Detection of occult
lymphoma in the peripheral blood and bone marrow of patients with
untreated early-stage and advanced-stage follicular lymphoma. J Clin
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