Peripheral T-cell lymphoma and large B-cell lymphoma (large transformed cell
lymphoma) are both intermediate grade lymphomas, according to the Working
Formulation of Non-Hodgkins Lymphomas. For intermediate grade lymphomas,
cure rates with initial chemotherapy are 40% to 45%.1 Patients with
anaplastic large T-cell lymphoma have a prognosis similar to that of patients with large
B-cell lymphoma, whereas patients with peripheral T-cell lymphoma have a cure
rate nearer to 20%.2 Mantle cell lymphoma is a small cell lymphoma distinct
from diffuse, small cleaved cell lymphoma. Although response rates to initial
therapy are excellent, relapses often occur, and cures with any
treatment - including stem cell transplantation - are extremely rare. Small
cleaved cell lymphoma is a slowly progressive, indolent, incurable lymphoma
except in very rare patients with stage I disease, who may be cured by
radiation therapy. This patient has stage III disease. Small noncleaved cell
lymphoma (Burkitts lymphoma) is a high-grade lymphoma with a 20% to 40%
chance of cure with aggressive combination chemotherapy. However, survival in
the absence of a complete remission is usually quite brief.
- Large B-cell lymphoma (large transformed cell lymphoma).
1. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard
regimen (CHOP) with three intensive chemotherapy regimens for advanced
non-Hodgkins lymphoma. N Engl J Med 1993;328:1002-6.
2. Siegert W, Agthe A, Griesser H, et al. Treatment of
angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma using
prednisone with or without the COPBLAM/IMVP-16 regimen. A multicenter study.
Kiel Lymphoma Study Group. Ann Intern Med 1992;117:364-70.
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