Small left colon syndrome (SLCS) is a well-documented clinical entity that is seen only in infants with mothers who have gestational diabetes. The obstruction is often high grade and has a transition zone similar to that seen in Hirschsprungs disease. The syndrome is thought to be caused by transient dysmotility secondary to hypoglycemia. No anatomic abnormality is present. Infants with SLCS should undergo work-up for cystic fibrosis and Hirschsprungs disease.