Advancing age, weight loss, and female sex are associated with increased cholesterol secretion into bile. In addition, advancing age and weight loss are associated with decreased bile acid synthesis. Weight loss also is correlated with gallbladder hypomotility. All three factors predispose to gallstone formation. Estrogen usage has been associated with the formation of gallstones. Sertraline use has not been associated with the formation of gallstones.1,2
- Use of sertraline.
1. Attili AF, Capocaccia R, Carulli N, et al. Factors associated with gallstone disease in the MICOL experience: Multicenter Italian Study on Epidemiology of Cholelithiasis. Hepatology 1997;26:80918.
2. Jensen KH, Jorgensen T. Incidence of gallstones in a Danish population. Gastroenterology 1991;100:7904.
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