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Family Medicine

Answer 2
  1. GnRH agonists. Osteoporosis can occur secondary to any condition or medication that causes accelerated bone loss.2 Conditions that may cause secondary osteoporosis include athletic amenorrhea, anorexia nervosa, hyperthyroidism, type 1 diabetes mellitus, and malabsorption syndromes. Medications that can cause secondary osteoporosis include excessive use of thyroid hormone, oral corticosteroids (taken for > 3 months’ duration), GnRH agonists, phenytoin, phenothiazines, long-term heparin, and phenobarbital. ACE inhibitors and zinc deficiency do not cause osteoporosis.

    2. South-Paul JE. Osteoporosis: part I. Evaluation and assessment. Am Fam Physician 2001;63:897–904.

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