Pioglitazone and rosiglitazone are the newest insulin sensitizer medications approved by the US Food and Drug Administration. They are thiazolidinediones, a class of medications that reduce insulin resistance and increase insulin sensitivity in the peripheral tissues (eg, liver, muscle). Of the other classes of drugs used to treat diabetes mellitus, sulfonylureas are the pancreas secretagogues, biguanides (eg, metformin) diminish the hepatic gluconeogenesis, and the alpha-glucosidase inhibitors (eg, acarbose) interfere with the intestinal absorption of carbohydrates.
- Increased sensitivity of peripheral tissues to insulin.
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