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Self-Assessment Questions


Answer 4
  1. Reducing influx of calcium to the cell. Verapamil hydrochloride, nifedipine, and diltiazem hydrochloride are all slow calcium-channel antagonists that reduce influx of calcium to the cell, resulting in vasodilation of vascular smooth muscle and increased coronary blood flow, especially to the epicardial region. These drugs have complex mechanisms of action. Slow calcium-channel blockers have a rather selective effect on cardiovascular functions, with a direct action on the smooth muscle of the arteries.

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