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Answer 1
  1. HIV infection. The patient has chronic cough due to chronic viral respiratory infection. Chronic infection, failure to thrive, generalized lymphadenopathy, and hepatosplenomegaly are frequent clinical symptoms and signs of HIV infection in children. Lymphadenopathy and hepatosplenomegaly are not commonly seen in patients with SCID. Bruton’s agammaglobulinemia is associated with low immunoglobulin levels in all isotypes (IgG, IgA, and IgM) and paucity of lymphoid tissues; it usually presents with recurrent bacterial infection.

     Bonilla FA, Geha RS. 12. Primary immunodeficiency diseases [published erratum appears in J Allergy Clin Immunol 2003;112:267]. J Allergy Clin Immunol 2003;111(2 Suppl):S571-81.

    2. Mouthon L, Lortholary O. Intravenous immunoglobulins in infectious diseases: where do we stand? Clin Microbiol Infect 2003;9:333-8.

    3. Tangsinmankong N, Bahna SL, Good RA. The immunologic workup of the child suspected of immunodeficiency. Ann Allergy Asthma Immunol 2001;87:362-9.

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