Answer 2 One-time IM injection of ceftriaxone and oral azithromycin. Because this patient is experiencing purulent urethral discharge, diagnostic testing will most likely reveal gonorrhea. Because of increasing resistance, the Centers for Disease Control and Prevention no longer recommends the use of fluoroquinolones for the treatment of gonococcal infections. Gonorrhea can be treated with a one-time IM injection of ceftriaxone 125 to 250 mg. In addition, all patients with gonorrhea should be routinely treated for Chlamydia infection (nearly 50% of patients with gonorrhea are coinfected with Chlamydia). A single dose of azithromycin 1 g orally is as effective as a standard 7-day course of doxycycline in achieving clinical cure of chlamydial infection. Click here to return to the questions
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