Answer 1 Doxycycline 100 mg orally twice daily for 14 days. Alternative treatments for syphilis in penicillin-allergic patients are a 2-week course of doxycycline 100 mg orally twice daily, tetracycline 500 mg orally 4 times daily, or erythromycin 500 mg orally 4 times daily. Data on the efficacy of single-dose azithromycin are lacking, and treatment failures have been reported. Resistance with macrolide antibiotics has also been reported. Single-dose ceftriaxone has not been proven effective in primary syphilis. Click here to return to the questions
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