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Review
of Clinical Signs

Nikolsky’s Sign

Series Editor and Author: Frank L. Urbano, MD

1. Which of the following statements does NOT apply to autoimmune skin disorders?
  1. Blistering of the skin is the most notable clinical characteristic of these disorders
  2. Histologic findings include intraepidermal splits
  3. Nikolsky’s sign can help differentiate these disorders
  4. Pemphigoid disorders are absent from this classification
  5. These disorders are characterized by weakened cell-cell adhesion or acantholysis
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2. Patients with which of the following disorders do NOT routinely exhibit a positive Nikolsky’s sign?

  1. Bullous impetigo
  2. Epidermolysis bullosa
  3. Pemphigus foliaceus
  4. Systemic sclerosis
  5. Toxic epidermal necrolysis
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  3. Which of the following is a characteristic of Nikolsky’s sign
  1. It can be elicited only by exerting pressure on normal skin in patients with pemphigus
  2. It can indicate the prognosis of patients with blistering skin diseases
  3. It frequently is positive in patients with bullous pemphigoid
  4. It usually is painless
  5. It occurs exclusively on the skin and on no other mucosal surfaces
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