Nikolsky’s Sign Series Editor and Author: Frank L. Urbano, MD
	1. Which of the following statements does NOT apply to autoimmune skin disorders? Blistering of the skin is the most notable clinical characteristic of these disorders Histologic findings include intraepidermal splits Nikolsky’s sign can help differentiate these disorders Pemphigoid disorders are absent from this classification These disorders are characterized by weakened cell-cell adhesion or acantholysis Click here to compare your answer. 2. Patients with which of the following disorders do NOT routinely exhibit a positive Nikolsky’s sign? Bullous impetigo Epidermolysis bullosa Pemphigus foliaceus Systemic sclerosis Toxic epidermal necrolysis Click here to compare your answer.		3. Which of the following is a characteristic of Nikolsky’s sign It can be elicited only by exerting pressure on normal skin in patients with pemphigus It can indicate the prognosis of patients with blistering skin diseases It frequently is positive in patients with bullous pemphigoid It usually is painless It occurs exclusively on the skin and on no other mucosal surfaces Click here to compare your answer.
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