Answer 1 Cushing’s syndrome. Cushing’s syndrome refers to the manifestations of hypercortisolism. The most striking features are central obesity, moon facies, violaceous striae, and hirsutism. Rapid weight gain is the most common presenting manifestation. Patients with Addison’s disease present with fatigue and hypotension. Violaceous striae are typically not a sign of PCOS. Although patients with Conn’s disease would present with hypertension, they would not have the other manifestations of Cushing’s syndrome. In CAH, serum cortisol would be decreased and additional laboratory testing (dehydroepiandrosterone sulfate and 17-hydroxyprogesterone) would be required. Click here to return to the questions
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