Dysphagia, Hoarseness, and Weakness in a 12-Year-Old Girl
Edrophonium chloride challenge.
Edrophonium chloride (Tensilon) should be given when a known myasthenia gravis patient presents with worsening weakness. A positive response (improved muscle strength) suggests a myasthenic crisis, which should be treated appropriately with intravenous immunoglobulin or plasmapheresis. A negative response (muscle fasciculations or respiratory depression) indicates cholinergic overdose.
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