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Pediatric Rounds Review Questions
Headache and Forehead Swelling in a 9-Year-Old Boy with Sinusitis

Answer 4

  1. Cefazolin/gentamicin. Cefazolin has bactericidal effect against Staphylococcus aureus (including penicillinase-producing strains), group A ß-hemolytic streptococci, and Haemophilus influenzae. Co-administration with an aminoglycoside adds coverage for gram-negative organisms, but this combination does not provide adequate coverage for anaerobic organisms such as Bacteroides species, which are often found in patients with sinusitis with intracranial involvement.

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