Headache and Forehead Swelling in a 9-Year-Old Boy with Sinusitis
Cefazolin has bactericidal effect against Staphylococcus aureus (including penicillinase-producing strains), group A ß-hemolytic streptococci, and Haemophilus influenzae. Co-administration with an aminoglycoside adds coverage for gram-negative organisms, but this combination does not provide adequate coverage for anaerobic organisms such as Bacteroides species, which are often found in patients with sinusitis with intracranial involvement.
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