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 Pediatric Rounds Review Questions
A Lethargic Infant with Vomiting

Answer 3

  1. Glutathione. Hepatotoxicity from acetaminophen poisoning results from the formation of NAPQI by the cytochrome P-450 system. NAC is a precursor for glutathione, which conjugates with NAPQI, leading to the formation and excretion of nontoxic mercapturate conjugates.

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