Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Where We Are Indexed
Past Issue Archives
Clinical Communication
In Review
Editorial Board
Information for Authors
Author Form

Reprints, Permissions, & Copyright
Site Map
BACK ISSUE articles are $15 each.
International credit cards NOT accepted.

JCOM Paid Subscribers
user name:
Forgot password?

JCOM Abstract

J Clin Outcomes Manage 
2012 Sep;19(9):414-419
Update on the treatment of hepatitis C genotype 1
Curry MP, Bleibel W

Abstract Objective: To review treatment of hepatitis C viral (HCV) infection genotype 1. Methods: Review of the literature in the context of 4 clinical cases. Results: HCV infection affects over 180 million people worldwide with the majority of individuals exposed to the virus developing chronic infection. The success rate of treatment of HCV genotype 1 has increased over the years with the evolution of therapeutic regimens, including the recent addition of direct-acting antiviral agents (DAAs). The sustained virologic response rate has increased from about 10% with initial treatment regimens to over 75% with triple therapy with a DAA and pegylated interferon/ribavirin combination. In addition, the treatment duration has been shortened without significant reduction in response rate. Adding new drugs to HCV treatment regimen increases the complexity of the treatment algorithms, associated side effects, and cost of the therapy. Conclusion: HCV treatment has significantly changed over the past decades with success rates dramatically increasing. This success is expected to reduce the number of patients infected with HCV and subsequently reduce the prevalence of HCV-induced cirrhosis, liver failure, and hepatocellular carcinoma.

Case-Based Review

Free Download

Search the Turner White index to find abstracts of articles published in JCOM.

New issues are posted one month following publication of the printed journal.

View past issue archives:    2013    2012    2011    2010    2009    2008    2007
   2006    2005    2004    2003     2002     2001     2000     1999

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2018, Turner White Communications
Updated 1/20/14 • jdw