Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Where We Are Indexed
Past Issue Archives
Clinical Communication
In Review
Editorial Board
Information for Authors
Author Form

Reprints, Permissions, & Copyright
Site Map
BACK ISSUE articles are $15 each.
International credit cards NOT accepted.

JCOM Paid Subscribers
user name:
Forgot password?

JCOM Abstract

J Clin Outcomes Manage 
2010 Sep;17(9):415-421
Treatment issues in anemia of chronic kidney disease
Saliba W, Antonios S, Abdallah J

Abstract Objective: To review the pathophysiology and approach to management of chronic kidney disease (CKD)–related anemia. Methods: Review of the literature. Results: CKD is an increasingly common medical condition in the United States. It is associated with a myriad of complications, among which anemia is perhaps the most treatable. Anemia has a high impact on the morbidity and mortality of patients with CKD, mainly by inducing left ventricular hypertrophy. CKD-related anemia is primarily due to erythropoietin insufficiency, but absolute and functional iron deficiency, iron restriction, and erythropoietin resistance are also factors. In recent years, hepcidin has emerged as an important player in iron homeostasis and the pathophysiology of iron restriction and represents a potential target for future therapeutic approaches. Early diagnosis and evaluation of anemia are fundamental in the management of patients with CKD and should include iron status assessment. Treatment relies on a combination of erythropoietin and iron supplementation, but the optimal hemoglobin target and threshold at which to treat are still debated. Conclusion: Effective treatment of CKD-related anemia can reduce cardiovascular complications, slow progression of renal failure, and improve quality of life.

Clinical Review Article

Search the Turner White index to find abstracts of articles published in JCOM.

New issues are posted one month following publication of the printed journal.

View past issue archives:    2013    2012    2011    2010    2009    2008    2007
   2006    2005    2004    2003     2002     2001     2000     1999

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2018, Turner White Communications
Updated 1/20/14 • jdw