Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Where We Are Indexed
Past Issue Archives
Clinical Communication
In Review
Editorial Board
Information for Authors
Author Form

Reprints, Permissions, & Copyright
Site Map
BACK ISSUE articles are $15 each.
International credit cards NOT accepted.

JCOM Paid Subscribers
user name:
Forgot password?

JCOM Abstract

J Clin Outcomes Manage 
2009 Sep ;16(9):415-428
HIV and hepatitis C virus coinfection: approach to management
Reese L, Chasan R, Fishbein DA

Abstract Objective: To review screening, diagnosis, and treatment in patients with HIV and hepatitis C virus (HCV) coinfection. Methods: Review of the literature in the context of a clinical case. Results: All persons with HIV should be routinely screened for HCV infection, as chronic hepatitis C has become a major source of mortality among HIV-infected persons. The course of liver disease is more rapid in HIV/HCV coinfected persons, and the risk for cirrhosis is nearly twice that in persons with HCV monoinfection. Prior to therapy, it is important to assess for contraindications to treatment, such as uncontrolled depression or pregnancy, and to obtain HCV genotype and quantitative HCV RNA. The standard treatment regimen is pegylated interferon alfa with weight-based ribavirin. During treatment, regular monitoring for bone marrow suppression and depression from pegylated interferon and hemolytic anemia from ribavirin is necessary. Certain antiretrovirals, such as zidovudine and didanosine, should be avoided during treatment for HCV as they may worsen treatment-related side effects. Treatment options are limited in relapsers and nonresponders but may include retreatment or even consensus interferon; for decompensated liver disease, referral for liver transplantation should not be delayed. Specifically targeted anti-HCV agents are under investigation and appear promising in monoinfected persons. Conclusion: Although much progress has been made in understanding HIV/HCV coinfection, an urgent need for further research remains.

Case-Based Review

Search the Turner White index to find abstracts of articles published in JCOM.

New issues are posted one month following publication of the printed journal.

View past issue archives:    2013    2012    2011    2010    2009    2008    2007
   2006    2005    2004    2003     2002     2001     2000     1999

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2018, Turner White Communications
Updated 1/20/14 • jdw