Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Where We Are Indexed
Past Issue Archives
Clinical Communication
In Review
Editorial Board
Information for Authors
Author Form

Reprints, Permissions, & Copyright
Site Map
BACK ISSUE articles are $15 each.
International credit cards NOT accepted.

JCOM Paid Subscribers
user name:
Forgot password?

JCOM Abstract

J Clin Outcomes Manage 
2009 Oct;16(10):468-480
Optimizing antiepileptic treatment
Parkerson KA, Pathmanathan JS, Milligan TA

Abstract Objective: To describe the properties of the available antiepileptic drugs (AEDs) and to provide a framework for tailoring antiepileptic therapy to the individual patient. Methods: Review of the literature. Results: The decision of when to begin antiepileptic therapy is a challenging one, and the benefits of treatment must be carefully weighed against the risk of adverse effects and costs. The number of therapeutic options is staggering, and a framework is needed to make appropriate drug choices. Decisions must take into account (1) efficacy against specific seizure types and epileptic syndromes, (2) pharmacologic properties, and (3) potential adverse effects and interactions with other medications. In general, drug monotherapy is the ideal strategy for seizure control. Approximately 50% of newly diagnosed patients become seizure-free on the first drug initiated and approximately 70% with switching to a second or third drug. Conclusion: Approximately 70% of those with epilepsy can achieve successful remission (5 or more years without a seizure) with medical therapy. For refractory cases, there have also been advances. However, epilepsy remains a difficult and in some cases disabling chronic illness.

Clinical Review

Search the Turner White index to find abstracts of articles published in JCOM.

New issues are posted one month following publication of the printed journal.

View past issue archives:    2013    2012    2011    2010    2009    2008    2007
   2006    2005    2004    2003     2002     2001     2000     1999

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2018, Turner White Communications
Updated 1/20/14 • jdw