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JCOM Abstract


J Clin Outcomes Manage 
2007 Oct;14(10):547-553
Clinical, family, and cost outcomes of preterm births: an overview of the problem and prevention opportunities
Armstrong J, Meis PJ

Abstract Objective: To describe the impact of preterm birth on morbidity and mortality rates and costs to society as well as to review prevention strategies, specifically focusing on the use of 17 ?-hydroxyprogesterone caproate (17P). Methods: Review of the literature. Main results: Preterm birth is the leading cause of infant death and pediatric neurodevelopmental disability in the United States and an important cause of chronic illness in children. The incidence of preterm birth has been slowly rising despite advances in obstetric health care. Preterm birth exacts an enormous societal economic toll, estimated at $26.2 billion in 2005 or $51,600 per preterm infant. A woman who has a spontaneous preterm birth is at high risk for a subsequent preterm birth. Recent trials have confirmed the use of progesterone beginning in the second trimester as an effective intervention. Conclusion: Effective interventions to prevent preterm birth remain elusive. Use of 17P has shown efficacy for reducing the risk of a recurrent preterm delivery

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